Feline Hepatocytes: Advancing Feline Liver Research and Veterinary Medicine

Feline hepatocytes are versatile tools in scientific research due to their unique biological characteristics. In basic cell biology research, they are used to study metabolic mechanisms, such as lipid, carbohydrate, and protein metabolism, as well as detoxification processes like glutathione metabolism. Their subcellular structures, including mitochondria, endoplasmic reticulum, and lysosomes, provide insights into energy metabolism, protein synthesis, and autophagy.

 In virology and infectious disease research, feline hepatocytes serve as models to study the replication mechanisms of viruses like FIPV and FeLV, and to explore host-virus interactions and immune responses. They also help investigate cross-species infection potential of certain viruses.

 For pharmacology and toxicology studies, feline hepatocytes are valuable for assessing drug metabolism and hepatotoxicity, particularly for drugs like acetaminophen that exhibit species-specific toxicity. They also aid in evaluating the toxicity of nanoparticles and chemicals.

 In the field of gene editing and disease modeling, CRISPR-edited feline hepatocytes help researchers study genetic liver diseases and liver cancer mechanisms. Lastly, in comparative medicine and evolutionary biology, comparing feline hepatocytes with those from other species reveals evolutionary adaptations and unique metabolic features. They also contribute to studies on liver regeneration and its underlying signaling pathways. Overall, feline hepatocytes offer a wealth of opportunities for advancing our understanding of liver biology and disease.

Milecell Bio offers high - quality hepatocytes and subcellular fractions of felines.

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Feature

The hepatocytes are plated at a density of 0.6 million per well in a 12 - well plate.